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ea0099p555 | Reproductive and Developmental Endocrinology | ECE2024

Klinefelter syndrome is associated with early-onset metabolic defects that are not reversed by testosterone therapy

Chouchane Karim , Hofbauer Susanna , Giordani Ilaria , nathalie vionnet , Barigou Mohammed , Pitteloud Nelly , Hauschild Michael , Papadakis Georgios

Background: Klinefelter syndrome (KFS) is the most common chromosomal aberration in men, characterized by an extra-X chromosome (47, XXY). Besides the well-known reproductive defects, KFS is characterized by a 4-fold increase in metabolic syndrome, cardiovascular morbidity and mortality. The exact cause of this constellation remains unclear.Methods: Data from non-mosaic KFS adults and adolescents, evaluated in the endocrine unit of Lausanne University Ho...

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ea0081rc12.4 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Unraveling the link between metabolism and reproduction in obese men

Papadakis Georgios , Lucie Favre , Zouaghi Yassine , Vionnet Nathalie , Niederlander Nicolas , Adamo Michela , Acierno James , Santoni Federico , Berdous Dassine , Spoerl Alexia , Paccou Emmanuelle , Aleman Yasser , Salamin Olivier , Hagmann Patrick , Messina Andrea , Pitteloud Nelly

Introduction: Obesity is a worldwide pandemic, and in men can often be associated with hypogonadotropic hypogonadism (HH), a finding consistent with a clear link between sex steroids and reproduction. In this study, we aimed to characterize the phenotypic spectrum of male obesity, focusing on the metabolic and reproductive effect of weight loss after bariatric surgery, as well as to explore the role of central inflammation.Methods: We conducted an observ...

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Endocrine Abstracts

Klinefelter syndrome is associated with early-onset metabolic defects that are not reversed by testosterone therapy

Unraveling the link between metabolism and reproduction in obese men

BiosciAbstracts